Extended Data Fig. 5: ID4 occurs in RNase H2 null RPE1 cells, particularly in transcribed regions.
From: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline
a–d, Mutational spectra detected by WGS after 100 population doublings in RPE1 cells demonstrates that SSTR and SNMH/MH deletions are enriched in RNase H2 null cells. Spectra for combined RNase H2 null and wildtype cell lines (a), and individual cell lines (b). Mutational signature analysis confirms ID4 contribution in RNase H2 null (c), but not WT cells (d). e, In RNase H2 null cells, ID4 contributes significantly more to indel mutations in transcribed genomic regions (P = 1.3 x 10−29). Two-sided Fisher’s exact test, ID4 indels vs other indels.
