Extended Data Fig. 9: The distribution of cysteine and serine protease clans.
From: Mechanism-based traps enable protease and hydrolase substrate discovery
The clan distribution of cysteine proteases from (a) animals and (b) viruses. The clan distribution of serine proteases from (c) animals and (d) viruses. We have demonstrated the Dap-mediated protease substrate capture method for multiple cysteine proteases (TEV (Clan PA), UL36USP (Clan CA) and SCoV2-PLpro (Clan CA)) and serine proteases (HtrA2 (Clan PA), RHBDL4 (Clan ST) and RBBP9 (Note that RBBP9 has not been included in the MEROPS database by September 30, 2021. RBBP9 possesses the “alpha-beta hydrolase” fold40, suggesting that it belongs to Clan SC). The data used to generate this figure were downloaded from the MEROPS database47.
