Extended Data Fig. 9: Ageing and rejuvenation similarity analysis.
From: Molecular hallmarks of heterochronic parabiosis at single-cell resolution
a–c, AGE (a), ACC (b), and REJ (c) DGE based cosine similarity matrices of the cell types studied, see Methods section ‘Ageing and rejuvenation similarity analysis’. All matrices are clustered with complete link hierarchical clustering. d, Force-directed network visualization of the STRING links between DEGs common to MSCs from GAT, MAT, SCAT, bladder, limb muscle, and diaphragm. e, Force-directed network visualization of the STRING links between DEGs common to MSCs (GAT and MAT), hepatocytes, basal and epidermal cells (skin), and HSCs and macrophages (marrow). All links with >0.9 STRING confidence score (scale from 0-1) are queried and shown. f, g Most enriched pathways (GO Biological Process) among the nodes of the networks shown in (d, e), combined scores are defined as in Enrichr50.
