Fig. 1: The sensitivity of SARS-CoV-2 Omicron to clinically approved monoclonal antibodies and to vaccine-elicited neutralizing antibodies.
From: Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

a, Titration of the monoclonal antibodies REGN10933 and REGN10897 individually and a combination of both against replication-competent Delta (top) and Omicron (bottom) viruses. Data are mean ± s.e.m. n = 4 of technical replicates at each dilution for each virus. Curve fitting for dose response was performed in GraphPad Prism. NT50, 50% neutralization titre. b, c, Neutralization of Delta (left) and Omicron (right) spike PV by sera from vaccinated individuals (ChAdOx-1 (b; n = 20) or BNT12b2 (c; n = 20)) over three time points after dose two (ChAdOx-1 or BNT162b2) and dose three (BNT162b2 only). Data are the geometric mean titre ± s.d., representative of two independent experiments each with two technical replicates. Statistical analysis was performed using Wilcoxon matched-pairs signed-rank tests; **P < 0.01, ***P < 0.001, ****P < 0.0001; NS, not significant.