Extended Data Fig. 3: Relation of GdmH to other proteins from the arginase superfamily.
From: Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
Unrooted neighbor-joining tree of 509 representatives of >15000 UniRef90 sequences with at least 27% identity to residues 60–390 of GdmH, selected and aligned with the ConSurf webserver61. Accession numbers of all sequences are given in Supplementary Data 2. The branches are colored according to the taxonomic group: Black: bacteria; cyan: archaea; bright green: fungi; green: plants; brown: stramenopile; magenta: animals. Branches containing selected enzymes with biochemically confirmed function are highlighted and demonstrate that very dissimilar sequences can have the same enzymatic activity in different taxa.
