Extended Data Fig. 6: Comparison of single- and multi-site BWAS (brain-wide association studies) sampling variability.
From: Reproducible brain-wide association studies require thousands of individuals
(a) Sampling variability of resting-state functional connectivity (RSFC) associations with the NIH Toolbox subscales in equally-sized samples (n = 877) from HCP (grey) and ABCD (red). Effect sizes (center of error bands) were matched across datasets (r = 0.06) to isolate sampling variability for a given effect. (b) Sampling variability of RSFC associations with the NIH Toolbox subscales in a single-site ABCD sample (site 16; n = 603; teal) and every other ABCD site (n = 3,325; red). Effect sizes (center of error bands) were matched across datasets (r = 0.06).
