Extended Data Fig. 6: Ro15-4513 cannot bind to the α4+/δ− interface.
From: Differential assembly diversifies GABAA receptor structures and signalling
a, b, Two views of Ro15-4513 bound in the α1+/γ2− benzodiazepine pocket of an α1β3γ2 receptor. c, d, Equivalent views of an α4β3δ receptor show that clashes with the side chains of R135 (α4+), E71 and H92 (δ−) prevent Ro15-4513 (and, likely, any benzodiazepine ligand) from binding to the α4+/δ− interface in the same mode as observed in α1β3γ2.
