Extended Data Fig. 7: Single-cell expression patterns of GABAAR subunits in the human cortex. | Nature

Extended Data Fig. 7: Single-cell expression patterns of GABAAR subunits in the human cortex.

From: Differential assembly diversifies GABAA receptor structures and signalling

Extended Data Fig. 7

a, Grouping cortical cell types by their GABAAR subunit expression. The majority of cell types (31) expresses a combination of 11 different GABAAR subunits, including α1-5, β1-3, δ and γ2-3. Cell type "Exc L5-6 THEMIS THTPA" expresses the highest number of subunits (14): α1-5, β1-3, δ, ε, γ1-3 and ρ1. Expression in this panel is binarized such that any subunit with a trimmed mean of summed intron and exon counts larger than 0 count per million (CPM) is considered as expressed (Methods). b, Heat map showing trimmed means of CPMs for every GABAAR subunit across individual cell types in the human cortex. Cell types are clustered by their gene expression profiles.

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