Extended Data Fig. 2: Survey of ligands bound in agonist pockets in different datasets.
From: Differential assembly diversifies GABAA receptor structures and signalling
a, α4β3δ and β3δ GABAARs solved in the absence of any known modulators. In both subtypes, HEPES is bound in the β3+/β3− agonist pocket under loop C. b, α4β3δ and β3δ GABAARs solved in the presence of 0.2 mM GABA and 1 mM histamine. c, α4β3γ2 and β3γ2 GABAARs solved in the presence of 0.2 mM GABA. d, α4β3δ and β3δ GABAARs solved in the presence of 1 mM THIP and 1 mM histamine. e, Summary table illustrating ligand vs interface compatibility. Empty spaces are left in cases where insufficient data is available to make a conclusion. For the GABA binding to β3+/γ2− pocket, a question mark indicates variable occupancy. f, Comparison of pore profiles of α4β3δ + GABA + histamine, α4β3δ + histamine, α1β3γ2 + alprazolam (6HUO) and α1β3γ2 + bicuculline (6HUK).
