Extended Data Fig. 3: Expression of various genes associated with CD8 T cytotoxicity and exhaustion.
From: Androgen receptor activity in T cells limits checkpoint blockade efficacy
a, Venn diagram and contingency table showing the significant overlap between CD8_R and CD8_k1 (Top, P < 0.0001) and between CD8_NR and CD8_k2 (Bottom, P < 0.0001). All cells: all the single cells that passed quality control in this study, as shown in Fig. 1a. Two-tailed Fisher’s exact test. b, Percentage of CD8_k1 or CD8_k2 clusters per sample in responders (n = 3 patients) and non-responders (n = 5 patients). Two-tailed unpaired Student’s t-test. Box center line, median; box, the interquartile range (IQR, the range between the 25th and 75th percentile); whiskers, 1.58 times IQR. c, d, Violin plot comparing the gene expression in CD8_k1 and CD8_k2 (c), and CD8_R and CD8_NR (d). R, responder; NR, non-responder
