Extended Data Fig. 7: Details of substrate-binding and of priming-induced conformational changes. | Nature

Extended Data Fig. 7: Details of substrate-binding and of priming-induced conformational changes.

From: Structure, substrate recognition and initiation of hyaluronan synthase

Extended Data Fig. 7

(a and b) Map quality for UDP-GlcNAc, UDP, and Mn2+ ligands. (c) Comparison of UDP and UDP-GlcNAc positions. (d) Map for the priming loop in nucleotide bound states. (e) Representative map for the GlcNAc primer. (f) Map for the priming loop in the primed states. (g) Contact point of TMH2 (open in blue, closed in grey) with IF1 in the primed state. (h and i) Map quality for TMH2 in a closed position (UDP-GlcNAc bound) and open position. All maps are contoured at 7.0σ.

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