Extended Data Fig. 2: scRNA-seq of human distal airways and alveoli.
From: Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
a. UMAPs show the expression of cell class specific marker genes. b. Dot plot indicates expression of cell type specific markers. c. UMAP shows the annotation of cell types from blood (c), endothelial (d), and mesenchymal (e) lineages. f. H&E reference sections and ST spots show the expression of RNASE1 in proximal (top) and distal airway (bottom). g. ST spots show the expression of MUC5AC, SFTPB, MUC5B and SCGB3A2 in proximal and distal airways as indicated. h. PLISH for RNASE1 (grey), MUC5B (green) and SFTPB (red) in proximal (top) and distal airways (bottom). blue (DAPI) indicates nuclei. Scale bar: 50 µm. i. Visualization of indicated epithelial cell transcriptomic signatures on ST tissue section from distal lung.
