Extended Data Fig. 4: C53-induced dilation of the binding pocket in the STING TMD.
From: Activation of STING by targeting a pocket in the transmembrane domain
a, Comparison of the TMD of human STING in the C53-bound and the apo states. It is evident that the TMD pocket in apo-STING is much smaller and cannot accommodate C53, and binding of C53 induces dilation of this pocket. b, Sequence alignment of the TMD of STING from human (h), mouse (m) and chicken (ch). Black circles highlight residues in the C53-binding pocket. Stars highlight residues in the TMD–TMD interface that contribute to the oligomerization of STING.
