Extended Data Fig. 4: Fit of the mechanistic enhancer–promoter model and robustness analysis.
From: Nonlinear control of transcription through enhancer–promoter interactions
a. Schematic description of the dynamics of the mechanistic model (here with two regulatory steps (n=2) for illustration). This case illustrates a scenario where, the enhancer–promoter interaction is long enough to allow the completion of the 2 regulatory steps and transiently increases the promoter activity. b. In an alternative scenario, the interactions are shorter but frequent enough to allow the completion of the 2 regulatory steps and transiently increase the promoter activity. c. Parameter values and 95% confidence intervals for the best fitting apparent two-state model. The rates are in the unit of RNA decay rate (\(\delta \)). d. Profile likelihood functions for all the parameters of the apparent two-state model. Red dashed lines show the threshold used to calculate the 95% confidence intervals (see Supplementary Model description for more details).
