Extended Data Table 2 Tethered agonist interaction distances in active-state aGPCRs and activity of GPR56 BFPP related mutants

From: The tethered peptide activation mechanism of adhesion GPCRs

  1. A, Distances for main TA interactions described in this study. The closest distance between residues is listed (+). B, G13 GTPγS binding activity stimulated by the recessive disorder GPR56 Bilateral Frontoparietal Polymicrogyria (BFPP) mutants. (#) ECL2 residue mutated BFPP R45.53W (R559 in GPR56 variant 2 used in the present study). (†) Residue mutated while exploring possible interactions with R559.
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