Extended Data Fig. 5: Comparison of human and Tetrahymena TERT structure.
From: Structure of active human telomerase with telomere shelterin protein TPP1
a, Superposition of RBD–RT–CTE ring (TERT ring) structures of hTERT and Tetrahymena TERT (TtTERT, PDB: 7LMA). b, Overlay of TEN–IFD-TRAP structures in human (colored) and Tetrahymena (gray) telomerase. Inset shows the secondary structure of human TRAP and the extended β sheet between TEN and TRAP. c–f, Comparison of human and Tetrahymena TEN–TRAP position relative to the TERT ring. Ribbon diagrams of the TERT rings from hTERT (c–d) and TtTERT (e–f) are shown in the same orientations as in A. Human and Tetrahymena TER are shown as magenta surfaces in c and e, respectively. Transparent sticks in d and f indicate the orientations of TRAP domains in hTERT and TtTERT, respectively. Residues located at the distal end of TRAP domains are shown as spheres. The hinge of the “rotation movement” is at the proximal end of TRAP that is connected to the IFDa and IFDc helices.
