Extended Data Fig. 9: Electrostatic interactions and conformational dynamics of the pseudoknot on TERT.
From: Structure of active human telomerase with telomere shelterin protein TPP1
a, Electrostatic surface of TERT shown in two different views. b–e, Cryo-EM density (upper) and model (lower) of telomerase catalytic core with P2 stem in State1-1 (b), State1-2 (c), State1–3 (d) and State2 (e). Through State1-1 to 1–3 (b–d), P2a.1 conducts an upward movement. From State1-1 (b) to State2 (e), P2a.1 and P2a move away from TEN domain of TERT with the J2a/b linker bulged out. The conformation of P2b and its location on TERT remain the same in the four structures.
