Extended Data Fig. 4: Secondary structure of human TER and interactions with TERT.
From: Structure of active human telomerase with telomere shelterin protein TPP1
a, Secondary structure observed in our telomerase structure (black), with unmodeled regions (gray) based on the telomerase database13. b, c, The previously predicted secondary structures of t/PK (b) and CR4/5 (c) based on phylogenetic analysis13. The dashed lines connecting residues in c indicate interactions forming the 3 bp P5.1 (highlighted) found in our structure, added for clarity. d, e, Structure-based schematics of TER P2b/P3-P1b (d) and CR4/5 (e) and interactions with TERT. Solid and dashed arrows from TERT residues to TER nucleotides indicate interactions with base and backbone, respectively. Base pair types are indicated using Leontis-Westhof symbols69. Red circles/ovals indicate residue positions with disease related mutations.
