Extended Data Fig. 3: Gene expression profiling reveals a stepwise development of microglia, meningeal and perivascular macrophages.
From: Specification of CNS macrophage subsets occurs postnatally in defined niches
(a) Heat map of the top 10 differentially regulated genes for each respective cell-type and time point. (b–e) Bar graphs depicting expression levels during development of microglia signature genes (b), CAM signature genes (c), transcription factors known to be expressed in macrophages (d) and Notch3 (e). Means ± s.d. are shown. Each dot represents an individual sample. N= 3 for E14.5, P3 and P10 microglia, E14.5, P3, P10, P21 and P56 mMΦ, P10 pvMΦ; n = 4 for P21 and P56 pvMΦ; n = 5 for P21 and P56 microglia.
