Extended Data Fig. 4: Polycomb body-enrichment of rixosome is EZH1/2- and RING1A/B-dependent.
From: Rixosomal RNA degradation contributes to silencing of Polycomb target genes
a, Immunofluorescence experiments showing colocalization of rixosome subunits MDN1 and WDR18 with the nucleolar marker NPM1 in wild-type (WT) and EZH1/2 double knockout cells, and with NPM1 and EZH2 in RING1A/B double knockout cells. Scale bar, 5 μm. b, c, Quantification of change in MDN1 (b) or NPM1 (c) foci per nucleus in the indicated cells. p values are from two-sided student’s t-tests. Data are presented as mean values +/− SEM.
