Extended Data Fig. 10: DNA methylation and gene expression analysis in mouse embryo and 2CLC.
From: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
a. Genome browser tracks visualization of DNA methylation levels measured by RRBS at the indicated naïve pluripotency (blue) and totipotency (red) loci of mouse embryonic stages38, ESC and 2CLC39. Each bar represents a single CpG and the height indicates the percentage of methylation. All reference datasets used in this study are summarized in Supplementary Table 8. b. Violin plots showing the log normalized expression of representative naïve pluripotency and totipotency genes in mouse early embryonic stages23 (left panel), ESC and 2CLC40 (right panel).
