Extended Data Fig. 13: Extended multiomics analysis of 8CLC chromatin landscape.
From: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
a. UMAP visualization of scRNA-seq in the multiomics analysis of stepwise e4CL-day 5 cells showing annotated 8CLC (13.5%) and non-8CLC clusters. b. Violin plot showing the log normalized expression of representative pluripotency and totipotency genes for 8CLC and non-8CLC of panel a. c. UMAP visualization of scATAC-seq in the multiomics analysis of stepwise e4CL-day 5 cells showing annotated 8CLC (5.1%) and non-8CLC clusters. d. Genome browser tracks visualization of chromatin accessibility for the indicated pluripotency and totipotency loci in 8CLC and non-8CLC of panel c.e . Venn diagram showing the overlap between 8CLC detected by scATAC-seq and 8CLC detected by scRNA-seq. f. Genome browser tracks visualization of chromatin accessibility and violin plot showing the gene expression for the indicated genes in 8CLC (cluster 5) and non-8CLC (all other clusters summed) of Fig. 2h
