Extended Data Fig. 17: Synergistic effect of TSA and DZNep on 8CLC induction.
From: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
a. Heatmaps showing the global gene expression differences in H9 ESC cultured in stepwise e4CL at day 5 with or without (w/o) either DZNep or TSA. Example genes are shown for each cluster. n = 2 technical replicates. 8CLC network hub genes are highlighted in red. b. Heatmaps showing the expression of totipotency genes in human PSC cultured in direct e4CL at day 7 with or without DZNep or TSA. n = 2 technical replicates. 8CLC network hub genes are highlighted in red.
