Extended Data Fig. 7: Asapiprant reversed neutrophilia but not lymphopenia in infected mice.
From: Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
Numbers of immune cells in the blood (a) and lung (b) of middle-aged C57BL/6 mice at 6 days after infection with 5000 PFU of SARS2-N501YMA30 with vehicle or asapiprant treatment starting at 2 dpi (n = 5 for uninfected controls; n = 10 vehicle- and asapiprant-treated mice). PMN: Polymorphonuclear neutrophils. P values determined by two-tailed Student’s t test. Data are mean ± s.e.m. Data are pooled from two independent experiments
