Fig. 5: High-resolution structures of miniprotein binders in complex with target proteins closely match the computational design models. | Nature

Fig. 5: High-resolution structures of miniprotein binders in complex with target proteins closely match the computational design models.

From: Design of protein-binding proteins from the target structure alone

Fig. 5

a–e, Left, superimposition of the computational design model (silver) on the experimentally determined crystal structure. Right, zoom-in view of the designed interface, with interacting side chains as sticks. a, H3 HA. b, TrkA. c, FGFR2. d, IL-7Rα. e, VirB8. f, Superimposition of the computational design model and refined cryo-EM structures of LCB1 (left) and LCB3 (right) bound to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein.

Back to article page