Extended Data Fig. 4: Cryo-EM data processing of amyloid fibrils from FTLD-TDP donors 1 to 4.
From: Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
a, Representative micrographs of PM1-3 from FTLD-TDP donor 1. Scale bar 500 Å. b, Representative 2D classes of PM1-3 from FTLD-TDP donors 1 to 4. 2D classes are stitched together to show a full cross-over of each morphology. c, 3D reconstructions of PM1-3 from the four FTLD-TDP donors. d, Distributions of the three fibril polymorphs in the four FTLD-TDP donors.
