Extended Data Fig. 5: Cryo-EM maps and FSC curves of FTLD-TDP donor 1.
From: Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
a, Views of the cryo-EM maps from FTLD-TDP donor 1 with five layers shown. b, FSC curves between two half-maps (left) and the cryo-EM reconstruction and refined atomic model (middle) of each polymorph PM1 (blue), PM2 (green), and PM3 (pink). FSC curves between cryo-EM reconstruction and the query model (red, Direction 1 chain of Extended Data Fig. 5a) and the atomic model of PM1 from FTLD-TDP donor 1 (blue) are compared on the right.
