Extended Data Fig. 6: Cryo-EM maps of TMEM106B fibrils from FTLD-TDP donors 1 to 4.
From: Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
The models of PM1-3 from donor 1 were rigid body fitted into the maps of PM1-3 from donors 2 to 4. These cryo-EM structures reveal that the polymorphs from all four donors share the same protofilament fold. Two subtypes of PM2 are exhibited by donors 1 and 4 (light green) and donors 2 and 3 (dark green), respectively.
