Extended Data Fig. 1: SpeB cleaves GSDMA.
From: Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes
a, Cytotoxicity of HEK293Ts transfected with human GSDMs ± SpeB. Data are the mean±s.d. of 4 technical replicates. P values were calculated by two-tailed Student’s t-test. b, Membranes spotted with lipids were incubated with indicated proteins and binding was assessed by immunoblot for GSDMA. c, Thermal melt analysis of GSDMA and GSDMAΔ240-247 with melting temperatures indicated. (a–c) data are representative of three independent experiments.
