Extended Data Fig. 10: Fgf17 is predominantly expressed in the brain by a subset of neurons and is downregulated with age.
From: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
a, Fgf17 is predominantly expressed in the brain based on the human protein atlas. b, Fgf17 is expressed by cortical glutamatergic neurons in the young adult mouse (Allen brain atlas). c, Sub-clustering of mouse cortical layer 4/5 neurons indicates expression by a subset of cortical neurons (Allen brain atlas). d, Gene set enrichment analysis of genes mostly correlated with Fgf17 in layer 4/5 neurons (Allen brain atlas). e, Fgf17 is expressed by cortical glutamatergic and GABAergic neurons in the human cortex (Allen brain atlas). f, Representative image of analysis in panel g. Scale bar, 100 μm. g, Fgf17 mRNA expression in cortical neurons drops dramatically in aged mice. (n = 3; two-way student t-test; mean ± s.e.m.). h, Fgf17 protein expression in cortical and hippocampal neurons drops dramatically in aged mice. (n = 3; mean ± s.e.m.). i, Representative images of analysis in panel h and Fig. 4f. Scale bar, 20 μm.
