Extended Data Fig. 4: TCR transduction and antigen specificity.
From: Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
(a) Experimental schema to transduce and measure \({{\bf{p}}}^{\text{WT}}\)-specific T cell receptor (TCR) activation. hVα,β = human α and β variable regions; mCα,β = mouse α and β constant regions. (b) Representative gating strategy to detect transduced TCR activation and specificity. (c–e) Sequences of model \({{\bf{p}}}^{\text{WT}}\)s and \({{\bf{p}}}^{\text{WT}}\)-specific TCRs, and TCR activation across varied \({{\bf{p}}}^{\text{WT}}\)concentrations.
