Fig. 2: Distribution of copy number signatures across human cancers.

Attributions of the 21 signatures (y axis) split by tumour type (x axis). The size of each dot represents the proportion of samples of each tumour type that shows the signature and the colour reflects the median attribution of the signature in each tumour type. Tumour/signature attributions with less than 5% of samples are not shown. Hierarchical clustering is shown below, sample sizes are shown above. ^aCN15 was identified from an extraction of high LOH samples (>70% of the genome LOH), and is not found at ≥5% frequency in any tumour type. ^bCN4 was identified in UVM at <5% frequency. Het mix, mixture of heterozygous segments.