Fig. 5: Clonal haematopoiesis dynamics and progression to myeloid disease.
From: The longitudinal dynamics and natural history of clonal haematopoiesis
a, Relationship between the growth rate associated with each driver gene in clonal haematopoiesis (CH), and the risk of AML progression associated with that driver gene. b, Relationship between the growth rate associated with each recurrent mutation in clonal haematopoiesis, and the strength of selection of that mutation in AML (circles) and MDS (triangles). In a, b, genes and hotspots that are mentioned in the main text are highlighted. AML risk intervals indicate standard error for the estimate5; error bars for dN/dS show 95% confidence intervals; error bars for annual growth show 90% HPDI. The confidence band (shaded region) represents the 95% confidence interval for the association between annual growth rates and AML risk or dN/dS.
