Extended Data Fig. 2: Distribution of somatic mutations within driver genes (previous page).

Lolliplots show the longest protein isoform of each gene, with protein domains depicted by grey rectangles. Each circle represents a somatic mutation. The vertical distance of the circle from the protein cartoon indicates its recurrence in the cohort (quantified on the y-axis). Amino acid codons recurrently mutated (ie. observed in more than one individual) in our cohort are explicitly labelled. Circle colours indicate the mutation type as per key. Non-truncating mutations (missense, inframe, synonymous) are depicted above and truncating mutations (nonsense, frameshift) below the protein cartoon.