Extended Data Fig. 8: Summary of associations between signatures and other covariates.
a, Main panel shows significant associations between copy number signatures and mutated genes. Gene annotations summarised in the panels below. Boxes with a red line indicate significant associations that were not considered when determining signature aetiologies as the significant enrichment was via amplification of the gene, which also resided in an ecDNA amplicon, which could be a consequence of the signature rather than a cause, potentially causing a spurious correlation with amplification signatures (CX8, CX9, CX11, CX13). b, Each row shows highly significant associations between signatures and different covariates. Unless otherwise specified, only positive correlations are shown.
