Extended Data Fig. 5: Monte Carlo simulation results for determining signature-specific noise thresholds.
a, Each plot (1 per signature) shows the interquartile range of sample signature activities after the introduction of noise in the copy number features using a Monte Carlo simulation. Samples are ordered by their observed signature activity (red line). b, Schematic showing how we fitted a Gaussian distribution to the simulated values of all samples with an observed signature activity of 0 (red line). The horizontal black line represents the quantile 0.95 of the fitted Gaussian and forms the basis of our signature specific noise threshold, where values below this line are not distinguishable from 0. c, Plot of the signature-specific thresholds for the 17 copy number signatures.
