Extended Data Fig. 4: Signalling and proliferation of o2R and o9R pmel T cells.
From: Potentiating adoptive cell therapy using synthetic IL-9 receptors
a, STAT1, STAT3 and STAT5 phosphorylation in o2R versus o9R pmel T cells after 30’ stimulation with MSA-oIL2 (5μM). Shown are MFI of individual biological duplicates, gated on YFP+ cells. **, p < 0.01; ****, p < 0.0001 (ANOVA). b, Shown are seven replicate experiments measuring in vitro proliferation (measured by fold growth) of o2R or o9R pmel T cells over 48 h in culture with MSA-oIL2, (each data point represents mean ± SD, n = 3). *, p < 0.05 (ratio paired t-test, two-sided).
