Extended Data Fig. 7: Sub-clustering of abundant cell types.
From: Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
a-f, Sub-clustering results for cardiomyocytes (n = 158,469) (a), fibroblasts (n = 147,219) (b), endothelial cells (n = 112,977) (c), pericytes (n = 69,304) (d), vascular smooth muscle cells (VSMC, n = 18,137) (e), and lymphocytes (n = 16,246) (f). Uniform manifold approximation and projection (UMAP) visualization colored by Leiden clusters is shown on the left. The distribution of sub-populations across patients by disease status represented as box plots with statistically credible changes indicated with a * (middle, see Methods). Sub-population labels are colored as in the UMAP visualization. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers. Dot plots of the most selective markers for each sub-population compared to all other sub-populations (right). The size of the dot reflects the percent of nuclei expressing the gene at non-zero levels and the shade reflects the mean log-normalized expression. Avg norm expr, Average log-normalized expression scaled to the max value for each gene; Pct Nuclei Expr > 0, Percent of nuclei expressing the gene at non-zero levels; Act. FB, Activated fibroblast; L-EC, Lymphatic endothelial.
