Fig. 2: Genome-wide association results for COVID-19.
From: A first update on mapping the human genetic architecture of COVID-19
a, The results of the genome-wide association study of hospitalized COVID-19 (n = 25,027 cases and n = 2,836,272 control individuals) (top), and the results of reported SARS-CoV-2 infection (n = 125,584 cases and n = 2,575,347 control individuals) (bottom). Loci highlighted in yellow (top) represent regions associated with the severity of COVID-19 manifestation. Loci highlighted in green (bottom) are regions associated with SARS-CoV-2-reported infection. Lead variants for the loci identified in this data release are annotated with their respective rs ID. Horizontal lines denote genome-wide significant thresholds. b, The results of gene prioritization using different evidence measures of gene annotation. Genes in regions of linkage disequilibrium (LD), genes with coding variants and eGenes (fine-mapped cis-eQTL variant PIP > 0.1 in GTEx Lung) are annotated if in linkage disequilibrium with a COVID-19 lead variant (r2 > 0.6). V2G denotes the highest gene prioritized by OpenTargetGenetics’ V2G score. The asterisk (*) indicates SARS-CoV-2 reported infection and the plus symbol (+) indicates COVID-19 severity. The transparent loci were reported in the previous freeze (data release 5), and loci in bright blue were identified in the current freeze (data release 6). This figure is reproduced from the original publication by the COVID-19 Host Genetics Initiative2 with modifications reflecting the updated analysis from data freeze 6.
