Extended Data Fig. 6: Conformational changes in TCA / preS1 binding pocket according to mutations of key residues that composite pocket.
From: Structural insights into the HBV receptor and bile acid transporter NTCP
a, Cartoon (left) and surface representation (right) of TCA / preS1 binding pocket of wild-type NTCP. Key residues are highlighted as ball-and-stick models and shown in blue. b, Cartoon (left) and surface representation (right) of TCA / preS1 binding pocket of quintuple mutant NTCP. The key residues are highlighted in green. Comparison of the binding pocket region of wild-type and quintuple mutant of NTCP. Three leucine residues located in the pathway of TCA transport and G158/S267 residues mentioned in previous studies were selected for mutagenesis. The quintuple mutant structure was obtained by homology modeling (SWISS-MODEL) using the wild-type NTCP structure.
