Fig. 4: Structural basis of NTCP recognition by Fab YN69083.
From: Structural insights into the HBV receptor and bile acid transporter NTCP
a, Orthogonal views of the NTCP–Fab YN69083 complex shown as molecular surfaces, separately coloured, of each Fab chain and NTCP domain. The intimate contact between the heavy chain and the panel domain is apparent. b, Blocking the TCA- and preS1-binding pocket by Fab YN69083. Top, NTCP alone, with the TCA- and preS1-binding pocket exposed on the extracellular face. Bottom, the Fab complex completely occludes the binding pocket, blocking entry of ligands from outside the cell. c, Details of the interaction between NTCP and Fab YN69083. Residues forming contacts are shown as stick models and labelled. Blue, NTCP; pink, Fab YN69083 heavy chain; purple, Fab YN69083 light chain. Intermolecular hydrogen bonds are shown as dashed yellow lines.
