Fig. 1: Robust infection of K18-hACE2 mice with the Delta and ancestral variants, but not with the Omicron variant.
From: Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination
a, Schematic of the experiment. Fifteen mice per group were intranasally infected with 104 p.f.u. of the indicated variant. Body temperature and weight were monitored daily. At 2, 4 and 7 days post-infection (d.p.i.), the upper respiratory tract and lungs were harvested and processed for downstream analysis. n = 5 per group. b, Changes in body temperature of mice infected with WA1, Delta and Omicron. Data are shown as the average ± s.d. and were analysed by two-way analysis of variance (ANOVA) and adjusted for multiple testing using the Bonferroni test. c, Severe weight loss of WA1-infected and Delta-infected mice. Data are shown as the average ± s.d. and were analysed by two-way ANOVA and adjusted for multiple testing using the Bonferroni test. The horizontal dashed lines in b,c indicate the baseline body temperature (b) and weight (c) of mice. d, Probability of survival of variant-infected mice. n = 10.
