Extended Data Fig. 8: RNA editing analysis in spleen RNA from Adar1^WT/mZα, Adar1^mZα/mZα, Adar1^−/mZα and Adar1^−/mZα Zbp1^−/− mice.

a, Normalised number of edits passing the statistical filters described in the Methods section, split according to the base substitution recorded, showing enrichment of the A > G editing profile associated with deamination of adenine. b, Violin plots of the per-site editing percentage for sites with detected editing. Solid horizontal lines show the median and dotted lines indicate quartiles. c, Edited sites detected in Adar1^WT/mZα mice, for reference, and the differential edits determined for the indicated comparisons were matched to annotated genomic features. The percentage of sites is shown for each category. d, Number of expected and observed editing sites in Adar1^WT/mZα mice are shown for families of repetitive elements for which either value exceeded 100. e, Number of expected and observed editing sites in Adar1^WT/mZα mice are shown for individual SINE families for which either value exceeded 100. f, Fold enrichment (observed/expected) for the SINE families shown in (e), showing detected edits within Adar1^WT/mZα mice, for reference, and differential edits within the indicated comparisons.

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