Extended Data Fig. 4: Macroscopic and histological analysis of adult Adar1^−/mZα mice deficient in ZBP1 or MAVS.

a, Representative images of mice with the indicated genotypes at about 15 weeks of age. b, Representative H&E-stained sections from indicated tissues of 15-week-old mice with the indicated genotypes. Scale bars, 200 μm. Periportal and pericentral areas in liver sections are marked with P and *, respectively. Pericentral sinusoidal dilatation in Adar1^−/mZα Mavs^WT/− liver section is outlined with dashed lines (top left and bottom right areas). Black arrows indicate dying epithelial cells in small intestinal sections. In a, b, control mice include littermates with Adar1^WT/mZα, Adar1^WT/− or Adar1^WT/WT genotypes. Control (n = 7), Adar1^−/mZα Zbp1^−/− (n = 11), Adar1^−/mZα Mavs^WT/− (n = 8), Adar1^−/mZα Zbp1^−/− Mavs^WT/− (n = 9), Adar1^−/mZα Mavs^−/− (n = 9), Adar1^−/mZα Zbp1^−/− Mavs^−/− (n = 7). Scale bar, 200 μm.