Extended Data Fig. 4: Structural relationship and amino acid conservation of the ligase complex components.
From: A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel
a, TMs1-4 of Pex2, Pex10, and Pex12 form similar structures. The upper panels show these TMs separately as cylinders, the lower panels show different views of their superposition. b, Shown is the degree of amino acid conservation among ligases of different species, as determined with the program ConSurf62 (scale on the side). c, As in b, but conservation shown with a space-filling model viewed from the lumen. d, Space-filling model of the membrane-embedded domain viewed from the front and back with amino acids colored according to their hydrophobicity. A hydrophilic cavity is indicated by an arrow.
