Extended Data Fig. 4: Transcriptional activity at active E/SEs targeted by SHM.
From: Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
a. Distribution of transcripts per million (TPM) values for hypermutated, not hypermutated, and inactive E/SEs identified in the 29 DLBCL cell lines. b. Distribution of TPM values for sense and antisense transcripts at the indicated chromatin domains, documenting divergent transcription (legend as in panel a). c. H3K27Ac ChIP–seq track (green) and RNA-seq tracks (red, antisense transcription; blue, sense transcription) at 4 representative loci targeted by SE-SHM. Green bar denotes the SEs identified by ROSE. BPM, bins per million (see methods). In panels a and b, pairwise comparisons between TPM values were significantly different across all categories and are thus not indicated (adjusted p < 0.05; Wilcoxon rank-sum test with BH correction).
