Extended Data Fig. 8: FishHook independently identifies E/SEs as recurrent mutational targets in DLBCL.
From: Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
a. Significantly mutated regions (1 kb) identified by FishHook in WGS data from the 93 DLBCL Discovery cases. The dotted line denotes the q-value at 10−6. Asterisks indicate peaks overlapping with hypermutated SEs identified by the integrated ChIP–seq-based approach presented in Extended Data Fig. 1 (see also Methods). b. The percentage of cases of primary DLBCL hypermutated across the 3,775 SEs identified. c. Overlap of significantly mutated 1 kb-regions called by FishHook (n = 164) with the union list of active SEs identified by ChIP–seq; data are shown for all SEs (n = 3,775, diagram on the far-left side) or for SEs hypermutated in at least 2 cases (n = 159, third diagram from the left). In a separate analysis, contiguous 1 kb FishHook regions falling within the same SE were stitched into loci, and the overlap between these loci (n = 66) and the union list of active SEs is provided on the second and fourth diagrams.
