Extended Data Fig. 9: SE-associated mutational signatures display features of AID activity.
From: Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
a. Cosine similarity of the three de novo mutational signatures identified in SEs (Fig. 1f) to the COSMIC signatures database. Blue slices in the pie reflect the degree of similarity with the COSMIC SBS signature listed to the left. Signatures with the highest similarity are highlighted in red (SBS9, non-canonical AID [ncAID]; SBS40, ageing; SBS84, AID). b. Cumulative activity of the three signatures at SEs, Es and the rest of the genome (WG) across the 93 cases of DLBCL, overall (left panels) and separately for GCB- and ABC-DLBCL (right panels). c,d. Mutation frequency of WRCY and non-WRCY motifs in E/SEs, as compared to random regions of equivalent size selected from the “rest of the genome”; data are shown for primary DLBCL biopsies (c) and cell lines (d). All p-values were calculated by two-sided Wilcoxon rank-sum test after BH correction.
