Extended Data Fig. 12: Mutations in the BCL6-B1BS influence DLBCL class assignment.
From: Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
a. Oncoplot of 223 cases of DLBCL classified into distinct genetic subtypes according to the LymphGen algorithm. Columns represent different cases of DLBCL and rows correspond to genetic alterations used by the LymphGen algorithm, with their overall percentage shown on the left. Colour coded keys below the plot indicate mutation type, presence/absence of BCL2 and BCL6 structural variants (SVs), presence/absence of mutations at the BCL2-NR3C1-, BCL6-BLIMP1-, and CXCR4-NR3C1-BS, and LymphGen class assignment, as obtained by running the algorithm without considering the BS mutations (LymphGen Original) or considering the BS mutations (LymphGen with BS mutations). b. Head-to-head comparison between LymphGen class assignments obtained as described in a. The results show 6 cases that changed class when including BS mutations, of which one was originally unclassified and became BN2 (purple), and 5 were originally classified and became “other” because they showed 0.5 < P(class) < 0.9 for multiple classes.
