Fig. 1: Cryo-EM structures of Dcr-2–Loqs-PD in different dsRNA-binding states.
From: Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
a, Schematic of Dcr-2, Loqs-PD and 50 bp dsRNA. Unless specified otherwise, the colour scheme of Dcr-2 and Loqs-PD is used throughout all of the figures. b, Cartoon model of Dcr-2–Loqs-PD in the apo state. The cap, core and base modules are labelled on the right. c, Cartoon model of Dcr-2–Loqs-PD–50 bp dsRNA dimer in the initial dsRNA-binding state (initial state). Molecule A is coloured, molecule B is shown in grey. d,e, Cartoon model of Dcr-2–Loqs-PD–50 bp dsRNA complex in the early-translocation (d) and mid-translocation (e) state. f,g, Cartoon model of Dcr-2–Loqs-PD–50 bp dsRNA complex in the active dicing (f) and post-dicing (g) state. The siRNA in g is coloured in goldenrod. The post-dicing state is shown as a transparent cryo-EM map. The model in c–g is aligned by base region. The components and resolution of each state are labelled below.
